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राष्ट्रीय असंचारी रोग कार्यान्वयन अनुसंधान संस्थान, जोधपुर

National Institute For Implementation Research On Non-Communicable Diseases, Jodhpur
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Dr. Vishal Singh

 Designation: Scientist - B

 Research interest: Biochemistry, Assessing health impact of air pollution, Cellular biology, Nanotherapeutics, Biosensors and Molecular biology

 Email: singh.vs@icmr.gov.in


 Brief Introduction:

Dr. Vishal Singh is currently working as Scientist – B at ICMR-NIIRNCD, Jodhpur, Rajasthan. He has completed his Ph.D. (2021) in the field of Biochemistry and his research majorly focused on nanobiotechnology. Dr. Vishal Singh has six years of research experience in the field of developing nanotherapeutics and nano-delivery systems for drugs/siRNA for the management of various non-communicable diseases. He has received various fellowship awards during his research career that includes an ICMR-Junior Research Fellowship, M.K Bhan Fellowship, and Eyes High Postdoctoral Match-Funding Fellowship at UCalgary, Canada. Currently, he is focused on assessing the impact of air pollution on respiratory health and determining the dynamics of zoonotic disease transmission under the One-Health approach.

 Academic Qualifications & Training:

1. B.Sc.  in Biochemistry-Honours from Panjab University, Chandigarh. 
2. M.Sc. in Biochemistry-Honours from Panjab University, Chandigarh.
3. Ph.D. in Biochemistry from Panjab University, Chandigarh and National Agri-Food Biotechnology Institute, Mohali.


1.	Gupta, S., Singh, V., Subramaniam, G., Singhal, NK., Sandhir, R., 2021. siRNA mediated GSK3β knockdown targets insulin signaling pathway and rescues Alzheimer’s disease pathology: Evidence from in vitro and  in vivo studies. Applied Materials and Interfaces (online published). (I.F-10.3)
2.	Sagar, P., Singh, V.,  Gupta, R., Kaul, S., Sharma, S., Kaur, S., Bhunia, R., Kondepudi, KK., Singhal, NK., 2021. pH triggered, synbiotic hydrogel beads for in vivo therapy of iron deficiency anemia and reduced inflammatory response. Applied Bio Materials (ACS), 4, 10, 7467–7484.
3.	Gupta, R., Kaul, S., Singh, V., Sandeep, K., Singhal, NK., 2021.  Graphene Oxide and Fluorescent aptamer based novel biosensor for detection of 25-hydroxyvitamin D3. Scientific Reports (Accepted). (I.F-4.996)
4.	Singh, V., Sagar, P., Kaul, S., Sandhir, R., Singhal, NK., 2020. Liver Phosphoenolpyruvate Carboxykinase-1 Downregulation via siRNA Functionalized Graphene Oxide Nanosheets Restores Glucose Homeostasis in Type 2 Diabetes Mellitus in-vivo Model. Bioconjugate Chemistry (ACS), 32, 2, 259–278. (IF- 6.029)
5.	Singh, V., Sandhir, R., Singhal, NK., 2020.  Synthesis, characterization and toxicity profiling of graphene oxide-metformin hydrogel as a sustained release system for metformin in-vitro. Materials Today: Proceedings, 36, 3,769-774. (IF- 1.8)
6.	Singh, V., Rakshit, K., Rathee, S., Angmo, S., Kaushal, S., Garg, P., Chung, J.H., Sandhir, R., Sangwan, R.S., Singhal, N.,  2016. Metallic / bimetallic magnetic nanoparticle functionalization for immobilization of α-amylase for enhanced reusability in bio-catalytic processes. Bioresource Technology. 214, 528–533. (IF- 11.889)
7.	Singh, V., Kaul, S., Singla, P., Kumar, V., Sandhir, R., Chung, J.H., Garg, P., Singhal, N., 2018. Xylanase Immobilization on magnetic and magnetic Core/Shell nanocomposites using two different flexible alkyl length organophosphonates: linker length and shell effect on enzyme catalytic activity. Int J Biol Macromol. 115, 590-599. (IF- 8.025)
8.	Patel, S.N ., Singh, V., Sharma, M., Sangwan, R.S., Singhal, N.K., Singh S.P.,  2017.Development of a thermo-stable and recyclable magnetic nanaobiocatalyst for bioprocessing of fruit processing residues and D-allulose synthesis. Bioresource Technology. 247, 633–639. (IF- 11.889)
9.	Kongot, M., Dohare, N., Singh, V., Reddy, DS., Singhal, NK., Patel, R., Kumar, A., 2018. A novel biocompatible NiII tethered moiety as a glucose uptake agent and a hit against methicillin-resistant Staphylococcus aureus. Eur J Pharm Sci. 123,335-349. (IF- 5.112)
10.	Kumari, A., Kaila, P., Tiwari, P., Singh, V., Kaul, S., Singhal, N., Guptasarma, P., 2018. Multiple thermostable enzyme hydrolases on magnetic nanoparticles: An immobilized enzyme-mediated approach to saccharification through simultaneous xylanase, cellulase and amylolytic glucanotransferase action. Int J Biol Macromol. 120, 1650-1658. (IF- 8.025)
11.	Kongot, M., Reddy, D., Singh, V., Patel, R., Singhal, NK., Kumar, A., 2018. Potent drug candidature of an ONS donor tethered copper (II) complex: Anticancer activity, cytotoxicity and spectroscopically approached BSA binding studies. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 212, 330-342. (IF- 4.831)
12.	Kongot, M.,  Reddy, D.,  Singh, V.,  Patel, R., Singhal, NK., Kumar, A., 2019. ONS donor entwined iron(III) and cobalt(III) complexes with exemplary safety profile as potent anticancer and glucose uptake agents. New J. Chem. 43. (IF- 3.925)
13.	Kongot, M.,  Reddy, D.,  Singh, V.,  Patel, R., Singhal, NK., Kumar, A., 2020. Oxidovanadium (IV) and iron (III) complexes with O2N2 donor linkage as plausible antidiabetic candidates: Synthesis, structural characterizations, glucose uptake and model biological media studies. Applied Organometallic Chemistry. 34 (2), e5327.  (IF- 4.072)
14.	Reddy, D., Kongot, M.,  Singh, V., Maurya, N., Patel, R., Singhal, NK., Avecilla, F., Kumar, A., 2019. Coumarin tethered cyclic imides as efficacious glucose uptake agents and investigation of hit candidate to probe its binding mechanism with human serum albumin. Bioorganic chemistry. 92, 103212. (IF- 5.307)
15.	Kongot, M.,  Reddy, D.,  Singh, V.,  Patel, R., Singhal, NK., Kumar, A., 2020. A manganese (II) complex tethered with S-benzyldithiocarbazate Schiff base: Synthesis, characterization, in-vitro therapeutic activity and protein interaction studies. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 231, 118123. (IF- 4.831)
16.	Kongot, M.,  Reddy, D.,  Singh, V.,  Patel, R., Singhal, NK., Kumar, A., 2020. Physicochemical, in-vitro therapeutic activity and biomolecular interaction studies of Mn(II), Ni(II) and Cu(II) complexes tethered with O2N2 ligand backbone. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 241, 118613. (IF- 4.831)
17.	Reddy, D., Kongot, M.,  Singh, V., Siddiquee, MA., Patel, R., Singhal, NK., Avecilla, F., Kumar, A., 2020. Biscoumarin–pyrimidine conjugates as potent anticancer agents and binding mechanism of hit candidate with human serum albumin. Archiv der Pharmazie. 354, 1, 2000181. (IF- 4.613)
18.	Nehra, M., Dilbaghi, A.N.,  Singh, V., Singhal, NK., Kumar, S., 2020. Highly Ordered and Crystalline Cu Nanowires in Anodic Aluminum Oxide Membranes for Biomedical Applications. physica status solidi. 217, 13. 
(IF- 2.17)

1.	Singh, V., Kaushal, S., Singhal, NK., 2019. Applications of Nanoagrochemicals: Precepts and Prospects (Book chapter) in Emerging trends in nanobiomedicine: Nanoagroceuticals and Nanophytochemicals.  1-14.
2.	Kaul, S., Singh, V., Sandhir, R., Singhal, NK., 2020. Organophosphonate functionalized Au/Si@ Fe3O4: Versatile carrier for enzyme immobilization. Methods in Enzymology. 630, 199-214.

 Complete Projects:


 Ongoing Projects: